10 Best Migraine Relief Medicines: Remedies to Relieve Your Pain

Migraine attacks can be debilitating, and finding the right medication can make a significant difference. From over-the-counter solutions to powerful combinations, the following list details some of the most effective options to alleviate migraine pain. Below are ten of the best migraine relief medications, along with a section for frequently asked questions (FAQs) on migraines and headaches to provide additional information on managing this condition. Read what NHS says about migraines.


1. Nurofen Plus

Nurofen Plus combines ibuprofen and codeine to provide dual-action pain relief. Ibuprofen reduces inflammation, while codeine, a mild opioid, works on the brain to reduce the sensation of pain, making this combination effective for severe migraines.


2. Migraleve

Migraleve is designed specifically for migraines and comes in two different types of tablets: pink tablets to target migraine pain at onset and yellow tablets for ongoing relief. These tablets contain paracetamol, codeine, and buclizine to combat pain and associated nausea, making it a comprehensive solution.


3. Panadol Advance

Panadol Advance is a simple yet effective option that contains paracetamol. Known for its quick-release formula, Panadol Advance is absorbed rapidly, making it a good option for mild to moderate headaches and migraines. Its gentle formulation is suitable for those who might have sensitive stomachs.


4. Anadin Extra

Anadin Extra combines aspirin, caffeine, and paracetamol for powerful pain relief. Aspirin and paracetamol reduce pain and inflammation, while caffeine enhances the effectiveness of the other two ingredients. This combination can be effective for migraines accompanied by fatigue or drowsiness.


5. Solpadeine Plus

Solpadeine Plus contains paracetamol, codeine, and caffeine for a well-rounded approach to migraine relief. This combination reduces pain and provides an added boost of energy from caffeine, which can counteract the tiredness that often comes with migraines.


6. Solpadeine Max

Solpadeine Max is a stronger version of Solpadeine Plus, with a higher dose of codeine and paracetamol. It’s especially useful for severe migraines where regular-strength options may not provide adequate relief. However, Solpadeine Max should only be used for short-term relief due to the risk of dependency on codeine.


7. Paracetamol

Paracetamol is one of the most widely available pain relievers and is effective for mild to moderate headaches and migraines. It has minimal side effects and is generally well-tolerated, making it suitable for frequent use, as long as dosage instructions are followed.


8. Night Nurse Capsules

Night Nurse Capsules are intended for nighttime relief and contain paracetamol, promethazine, and dextromethorphan. While not specifically formulated for migraines, Night Nurse can be useful for migraines that interfere with sleep, helping users rest through the pain.


9. Numark Cold & Flu Night Capsules

These capsules offer pain relief along with ingredients that address cold and flu symptoms. Containing paracetamol, promethazine, and dextromethorphan, they help reduce pain and promote rest, making them useful for migraines that occur alongside sinus or cold symptoms.


10. Nurofen Meltlets Lemon

Nurofen Meltlets Lemon contains ibuprofen and is designed to dissolve on the tongue without water, making it a convenient choice for on-the-go relief. As an anti-inflammatory, ibuprofen is effective for migraines with symptoms of inflammation, such as throbbing pain.


FAQs About Headaches and Migraine Relief

1. What is the difference between a headache and a migraine?
A headache typically causes mild to moderate pain and is often localized. Migraines are more severe, usually come with a throbbing or pulsing pain, and can be accompanied by nausea, vomiting, and sensitivity to light and sound.

2. Can lifestyle changes help reduce migraine frequency?
Yes, lifestyle changes such as maintaining a regular sleep schedule, managing stress, staying hydrated, and avoiding known migraine triggers (like certain foods or alcohol) can help reduce the frequency and intensity of migraines.

3. How do I know if a medication is working?
If your medication helps to reduce pain and associated symptoms within 30-60 minutes and provides lasting relief for several hours, it is likely effective. Always follow dosage recommendations and give a medication a few trials to judge its effectiveness.

4. Are over-the-counter migraine medications safe for regular use?
Many over-the-counter medications are safe when used occasionally. However, prolonged use can lead to medication-overuse headaches or dependency on certain ingredients like codeine. Consult a doctor if you’re using pain relief frequently.

5. Can I take multiple types of migraine medication at once?
Combining different medications can sometimes lead to increased side effects or adverse reactions. Always check with a healthcare professional before mixing medications.

6. What should I do if I experience side effects?
Common side effects include dizziness, drowsiness, or stomach upset. If you experience severe side effects, such as difficulty breathing, rashes, or swelling, stop taking the medication and seek medical help immediately.

7. How can I manage migraine symptoms without medication?
Non-medicinal strategies include applying cold compresses to the head, resting in a dark, quiet room, practicing deep breathing or relaxation techniques, and staying hydrated.

8. When should I seek medical advice for migraines?
If your migraines are severe, frequent, or unresponsive to over-the-counter treatments, or if you experience neurological symptoms (such as vision loss, slurred speech, or weakness), it’s best to consult a healthcare professional.


These ten medications offer a variety of approaches to managing migraines, allowing individuals to select options that suit their specific symptoms and preferences. Remember, while these over-the-counter options can provide significant relief, it’s essential to use them responsibly and to seek medical advice if your symptoms persist or worsen.